Sugi Predict

Sugi Predict / Compounds / SCHEMBL1265342

SCHEMBL1265342

SCHEMBL1265342

N[C@H]1CCOc2c(F)cccc21

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ADRA2A P08913 2/20 0.50
▸ KDM1A O60341 2/20 0.39
▸ KDM1B Q8NB78 1/20 0.39
▸ TERT O14746 1/20 0.37
▸ HTR2C P28335 2/20 0.36
▸ HTR2B P41595 2/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ TAAR1 Q96RJ0 1/20 0.36
▸ ADRA2B P18089 1/20 0.35
▸ ADRA1A P35348 1/20 0.35
▸ DRD2 P14416 1/20 0.34
▸ DRD3 P35462 1/20 0.34
▸ NOS3 P29474 1/20 0.34
▸ NOS1 P29475 1/20 0.34
▸ NOS2 P35228 1/20 0.34
▸ JAK2 O60674 4/20 0.33
▸ JAK3 P52333 4/20 0.33
▸ JAK1 P23458 1/20 0.33
▸ CYP19A1 P11511 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1265344 1.00 ADRA2A (0.50) ADRA2AKDM1AKDM1BTERTHTR2C
SCHEMBL1266132 1.00 ADRA2A (0.50) ADRA2AKDM1AKDM1BTERTHTR2C
Hydrochloric Acid SCHEMBL26962833 0.98 ADRA2A (0.49) ADRA2AKDM1AKDM1BTERTHTR2C
Hydrochloric Acid SCHEMBL1266175 0.98 ADRA2A (0.49) ADRA2AKDM1AKDM1BTERTHTR2C
Hydrochloric Acid SCHEMBL1266173 0.98 ADRA2A (0.49) ADRA2AKDM1AKDM1BTERTHTR2C
Hydrochloric Acid SCHEMBL30563578 0.98 ADRA2A (0.49) ADRA2AKDM1AKDM1BTERTHTR2C
SCHEMBL14275635 0.82 ADRA2A (0.50) ADRA2AKDM1AHTR2CHTR2BTAAR1
SCHEMBL31316850 0.82 ADRA2A (0.50) ADRA2AKDM1AHTR2CHTR2BTAAR1
SCHEMBL31278211 0.81 KDM1A (0.41) ADRA2AKDM1AKDM1BTERTHTR2C
Hydrochloric Acid SCHEMBL1162885 0.81 HTR2C (0.35) ADRA2AHTR2CHTR2BNOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743081-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION Pretzel Therapeutics, Inc. (US) 2026-05-20 — — EP disclosed
EP-4743453-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION Pretzel Therapeutics, Inc. (US) 2026-05-20 — — EP disclosed
WO-2025019407-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION PRETZEL THERAPEUTICS, INC. (US) 2025-01-23 — — WO disclosed
WO-2025015178-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION PRETZEL THERAPEUTICS, INC. (US) 2025-01-16 — — WO disclosed
US-20240150339-A1 Compounds and Their Use as PDE4 Activators MIRONID LIMITED (GB) 2024-05-09 — — US disclosed
EP-4291557-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2023-12-20 — — EP disclosed
CN-116848107-A Compounds and their use as PDE4 activators 米罗尼德有限公司 2023-10-03 — — CN disclosed
WO-2022172037-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS MIRONID LIMITED (GB) 2022-08-18 — — WO disclosed
EP-2326647-A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES AND 6-SUBSTITUTED 2-(IMIDAZOIOÝ4,5- C¨PYRIDINYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION Wyeth LLC (US) 2011-06-01 — — EP disclosed
US-7919490-B2 6-substituted 2-(benzimidazolyl)purine or purinones and 6-substituted 2-(imidazolo[4,5-c]pyridinyl)purine or purinones; Jak3 tyrosine kinase inhibitors; autoimmune and mast cell-mediated diseases, transplant rejection; antiinflammatory agents WYETH LLC (US) 2011-04-05 — — US disclosed
US-20080287468-A1 PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION PHARMACOPEIA, INC. (US) 2008-11-20 — — US disclosed
US-20080287468-A1 PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION PHARMACOPEIA, INC. (US) 2008-11-20 — — US disclosed
US-20080214580-A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION PHARMACOPEIA, INC. (US) 2008-09-04 — — US disclosed
US-20080119496-A1 7-Substituted Purine Derivatives for Immunosuppression PHARMACOPEIA DRUG DISCOVERY, INC. (US) 2008-05-22 — — US disclosed
US-20080119496-A1 7-Substituted Purine Derivatives for Immunosuppression PHARMACOPEIA DRUG DISCOVERY, INC. (US) 2008-05-22 — — US disclosed
US-20080085898-A1 8-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE DERIVATIVES FOR IMMUNOSUPPRESSION PHARMACOPEIA, INC. (US) 2008-04-10 — — US disclosed
WO-2008043031-A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION PHARMACOPEIA, INC. (US) 2008-04-10 — — WO disclosed
WO-2008011392-A2 PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION LIGAND PHARMACUETICALS INCORPORATED (US) 2008-01-24 — — WO disclosed
US-20070021443-A1 Purine and imidazopyridine derivatives for immunosuppression WYETH LLC 2007-01-25 — — US disclosed
US-20070021443-A1 Purine and imidazopyridine derivatives for immunosuppression WYETH LLC 2007-01-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119496-A1 7-Substituted Purine Derivatives for Immunosuppression P2RX7, P2RX5, P2RY1 ADRA2A 610/4885KDM1A 1077/4885KDM1B 2049/4885
US-20080085898-A1 8-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE DERIVATIVES FOR IMMUNOSUPPRESSION TPMT, KIT, ADORA2A ADRA2A 967/4885KDM1A 1002/4885KDM1B 1769/4885
US-20080214580-A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION P2RY6, P2RY1, P2RX6 ADRA2A 603/4885KDM1A 997/4885KDM1B 1573/4885
US-20070021443-A1 Purine and imidazopyridine derivatives for immunosuppression TPMT, P2RY4, P2RY1 ADRA2A 754/4885KDM1A 1830/4885KDM1B 2476/4885
US-20240150339-A1 Compounds and Their Use as PDE4 Activators PDE4A, PDE4B, PDE4C ADRA2A 100/4885KDM1A 3798/4885KDM1B 4082/4885
US-20080287468-A1 PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION TPMT, P2RY4, P2RY1 ADRA2A 754/4885KDM1A 1830/4885KDM1B 2476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.