Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700297 | 0.80 | OPRM1 (0.68) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4697321 | 0.77 | OPRM1 (0.54) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5483992 | 0.77 | OPRM1 (0.58) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4700090 | 0.75 | OPRM1 (0.59) | OPRM1OPRD1OPRK1KCNH2 | |
| Citric Acid SCHEMBL4755341 | 0.72 | OPRM1 (0.57) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4699192 | 0.71 | OPRM1 (0.50) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4698334 | 0.71 | OPRM1 (0.69) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4698378 | 0.70 | OPRM1 (0.51) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4702161 | 0.70 | OPRM1 (0.60) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4697637 | 0.69 | OPRM1 (0.71) | OPRM1OPRD1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440059-B1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2008-04-16 | — | — | EP | disclosed |