Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753659 | 0.88 | REN (0.42) | RENALDH1A1GAAL3MBTL1 | |
| SCHEMBL499126 | 0.79 | REN (0.53) | REN | |
| SCHEMBL499127 | 0.79 | REN (0.53) | REN | |
| SCHEMBL3008220 | 0.72 | REN (0.47) | REN | |
| SCHEMBL499055 | 0.68 | REN (0.55) | REN | |
| SCHEMBL499056 | 0.68 | REN (0.55) | REN | |
| SCHEMBL4755115 | 0.67 | SLC6A9 (0.37) | RENALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL3004738 | 0.65 | REN (0.55) | REN | |
| SCHEMBL2998864 | 0.65 | REN (0.55) | REN | |
| SCHEMBL499549 | 0.64 | REN (0.55) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |