Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499066 | 0.81 | MAPT (0.39) | KMT2AMEN1MAPTPOLBGAA | |
| SCHEMBL14050306 | 0.78 | POLB (0.55) | KMT2AMEN1MAPTPOLBGAA | |
| SCHEMBL27860619 | 0.74 | ERCC5 (0.51) | KMT2AMEN1MAPTERCC5FEN1 | |
| SCHEMBL25765618 | 0.74 | ALDH1A1 (0.46) | KMT2AMEN1MAPTERCC5FEN1 | |
| SCHEMBL8341052 | 0.74 | MEN1 (0.44) | KMT2AMEN1MAPTERCC5FEN1 | |
| SCHEMBL13889273 | 0.74 | HTT (0.50) | KMT2AMEN1POLBGAAALDH1A1 | |
| SCHEMBL19033244 | 0.73 | NOS2 (0.49) | KMT2AMEN1MAPTERCC5FEN1 | |
| SCHEMBL12157112 | 0.73 | MEN1 (0.44) | KMT2AMEN1MAPTERCC5FEN1 | |
| SCHEMBL3922315 | 0.73 | GSK3B (0.50) | KMT2AMEN1MAPTERCC5FEN1 | |
| SCHEMBL499263 | 0.72 | ATM (0.33) | MAPTALDH1A1NOS2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |