Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773641 | 1.00 | MEN1 (0.34) | MEN1KMT2AADRA2CALDH1A1MAPT | |
| SCHEMBL1773222 | 1.00 | MEN1 (0.34) | MEN1KMT2AADRA2CALDH1A1MAPT | |
| SCHEMBL17916068 | 0.72 | GSK3A (0.37) | KMT2AADRA2CALDH1A1MAPTGSK3A | |
| SCHEMBL17918622 | 0.72 | GSK3A (0.37) | KMT2AADRA2CALDH1A1MAPTGSK3A | |
| SCHEMBL17916070 | 0.72 | GSK3A (0.37) | KMT2AADRA2CALDH1A1MAPTGSK3A | |
| SCHEMBL12269060 | 0.72 | GSK3A (0.37) | KMT2AADRA2CALDH1A1MAPTGSK3A | |
| SCHEMBL23697813 | 0.69 | MEN1 (0.42) | MEN1KMT2AALDH1A1MGLLGBA1 | |
| SCHEMBL1774288 | 0.69 | MEN1 (0.42) | MEN1KMT2AALDH1A1MGLLGBA1 | |
| SCHEMBL10311254 | 0.69 | — | — | |
| SCHEMBL106970 | 0.69 | ADRA2C (0.35) | MEN1KMT2AADRA2CALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981507-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007089679-A3 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |