Sugi Predict

Sugi Predict / Compounds / SCHEMBL4756239

SCHEMBL4756239

SCHEMBL4756239

Cc1cc(C(=O)Nc2ncc(F)s2)c(OS(C)(=O)=O)cc1Br

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GCK P35557 2/20 0.41
▸ AHR P35869 1/20 0.39
▸ NPC1 O15118 4/20 0.39
▸ RAB9A P51151 4/20 0.39
▸ LMNA P02545 3/20 0.39
▸ SMN1; SMN2 Q16637 3/20 0.39
▸ MITF O75030 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ FBP1 P09467 5/20 0.36
▸ PKM P14618 1/20 0.35
▸ GPR27 Q9NS67 1/20 0.35
▸ POLQ O75417 2/20 0.35
▸ FFAR2 O15552 2/20 0.35
▸ MEN1 O00255 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4755980 0.79 RAB9A (0.48) GCKNPC1RAB9ALMNASMN1; SMN2
SCHEMBL25143151 0.69 RAB9A (0.54) NPC1RAB9ASMN1; SMN2ALDH1A1POLB
SCHEMBL4755965 0.65 RAB9A (0.48) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL4756248 0.65 MEN1 (0.43) GCKNPC1RAB9ALMNASMN1; SMN2
SCHEMBL4757154 0.65 FFAR2 (0.40) NPC1RAB9ALMNASMN1; SMN2FBP1
SCHEMBL12469108 0.64 FFAR2 (0.50) AHRNPC1RAB9ASMN1; SMN2FFAR2
SCHEMBL30395099 0.63 AHR (0.54) AHRNPC1RAB9ALMNASMN1; SMN2
SCHEMBL25220924 0.63 AHR (0.54) AHRNPC1RAB9ALMNASMN1; SMN2
SCHEMBL2371104 0.63 FFAR2 (0.52) LMNAFFAR2MAPT
SCHEMBL2136387 0.62 AHR (0.42) GCKAHRNPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES, L.C. 2012-05-17 — — US disclosed
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES, L.C. 2012-05-17 — — US disclosed
US-8124632-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES, L.C. (US) 2012-02-28 — — US disclosed
US-8124632-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES, L.C. (US) 2012-02-28 — — US disclosed
WO-2009035788-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. (US) 2009-03-19 — — WO disclosed
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. 2009-02-05 — — US disclosed
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. 2009-02-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC GCK 1360/4885AHR 842/4885NPC1 585/4885
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC GCK 1360/4885AHR 842/4885NPC1 585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.