Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 17/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499944 | 0.78 | MET (0.66) | MET | |
| SCHEMBL2494615 | 0.74 | MET (0.70) | MET | |
| SCHEMBL2495032 | 0.72 | MET (0.54) | MEN1KMT2AMET | |
| SCHEMBL2766096 | 0.66 | MEN1 (0.60) | MEN1KMT2A | |
| SCHEMBL1205105 | 0.66 | MEN1 (0.60) | MEN1KMT2A | |
| SCHEMBL27565565 | 0.66 | TBXAS1 (0.52) | CYP19A1TBXAS1MEN1KMT2A | |
| SCHEMBL31060346 | 0.64 | TBXAS1 (1.00) | CYP19A1TBXAS1MEN1KMT2A | |
| SCHEMBL4527869 | 0.64 | MET (0.56) | MET | |
| SCHEMBL15426079 | 0.62 | MEN1 (1.00) | MEN1KMT2A | |
| SCHEMBL1202774 | 0.60 | KMT2A (0.49) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |