Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753235 | 0.92 | KMT2A (0.52) | DHFRKMT2A | |
| SCHEMBL4755224 | 0.88 | DHFR (0.52) | DHFRKMT2AMEN1 | |
| SCHEMBL4755401 | 0.86 | DHFR (0.52) | DHFR | |
| SCHEMBL4753695 | 0.85 | MAPT (0.50) | DHFRKMT2A | |
| SCHEMBL4753856 | 0.84 | DHFR (0.48) | DHFRKMT2A | |
| SCHEMBL4755645 | 0.84 | DHFR (0.53) | DHFR | |
| SCHEMBL4756448 | 0.84 | DHFR (0.46) | DHFR | |
| SCHEMBL4753175 | 0.82 | DHFR (0.46) | DHFR | |
| SCHEMBL4753837 | 0.81 | DHFR (0.53) | DHFR | |
| SCHEMBL4753250 | 0.81 | ALDH1A1 (0.56) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |