Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | AKT2 | P31751 | 3/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756702 | 1.00 | GSK3B (0.50) | GSK3BPDPK1ALDH1A1CYP1A2AKT2 | |
| SCHEMBL4704718 | 0.94 | GSK3B (0.50) | GSK3BPDPK1ALDH1A1CYP1A2AKT2 | |
| SCHEMBL5425612 | 0.94 | GSK3B (0.50) | GSK3BPDPK1ALDH1A1CYP1A2AKT2 | |
| SCHEMBL5432249 | 0.89 | GSK3B (0.47) | GSK3BPDPK1AKT2LRRK2NOX4 | |
| SCHEMBL4705861 | 0.89 | GSK3B (0.47) | GSK3BPDPK1AKT2LRRK2NOX4 | |
| SCHEMBL5434768 | 0.87 | NOX4 (0.53) | GSK3BPDPK1AKT2LRRK2NOX4 | |
| SCHEMBL4705206 | 0.87 | NOX4 (0.53) | GSK3BPDPK1AKT2LRRK2NOX4 | |
| SCHEMBL3582428 | 0.85 | ALDH1A1 (0.44) | GSK3BPDPK1ALDH1A1CYP1A2AKT2 | |
| SCHEMBL3582425 | 0.85 | AKT2 (0.44) | GSK3BPDPK1ALDH1A1CYP1A2AKT2 | |
| SCHEMBL4759187 | 0.84 | ALDH1A1 (0.45) | GSK3BPDPK1ALDH1A1CYP1A2AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | claimed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | GSK3B 478/4885PDPK1 86/4885ALDH1A1 2379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.