Sugi Predict

Sugi Predict / Compounds / SCHEMBL4756752

SCHEMBL4756752

SCHEMBL4756752

CC(=O)Oc1cccc(OC(C)=O)c1C(=O)Nc1nc(S(C)(=O)=O)c(S(C)(=O)=O)s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 7/20 0.48
▸ TP53 P04637 3/20 0.42
▸ ALDH1A1 P00352 8/20 0.40
▸ MAPT P10636 5/20 0.40
▸ PPARG P37231 1/20 0.40
▸ NCOA2 Q15596 1/20 0.40
▸ NCOA1 Q15788 1/20 0.40
▸ HSD17B10 Q99714 3/20 0.40
▸ MEN1 O00255 5/20 0.39
▸ KMT2A Q03164 5/20 0.39
▸ RAB9A P51151 4/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ MLNR O43193 1/20 0.38
▸ NR1I2 O75469 1/20 0.38
▸ ABCB11 O95342 1/20 0.38
▸ ADRB2 P07550 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10114335 0.75 SMN1; SMN2 (0.45) KDM4ETP53ALDH1A1MAPTHSD17B10
SCHEMBL4757427 0.74 ALDH1A1 (0.47) KDM4ETP53ALDH1A1MAPTPPARG
SCHEMBL4756657 0.73 RAB9A (0.59) KDM4ETP53ALDH1A1HSD17B10MEN1
SCHEMBL4756620 0.72 ALDH1A1 (0.45) KDM4ETP53ALDH1A1MAPTHSD17B10
SCHEMBL10114116 0.72 NPC1 (0.54) TP53ALDH1A1MAPTHSD17B10MEN1
SCHEMBL10114897 0.71 RAB9A (0.42) KDM4ETP53ALDH1A1MAPTHSD17B10
SCHEMBL4756610 0.70 ALDH1A1 (0.46) KDM4ETP53ALDH1A1MAPTPPARG
SCHEMBL4757435 0.68 ALDH1A1 (0.44) KDM4ETP53ALDH1A1MAPTHSD17B10
SCHEMBL4756762 0.68 RAB9A (0.41) KDM4ETP53ALDH1A1MAPTHSD17B10
SCHEMBL5065111 0.68 ALDH1A1 (0.51) KDM4ETP53ALDH1A1MAPTPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES, L.C. 2012-05-17 — — US disclosed
US-8124632-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES, L.C. (US) 2012-02-28 — — US disclosed
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. 2009-02-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC KDM4E 2428/4885TP53 653/4885ALDH1A1 1605/4885
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC KDM4E 2428/4885TP53 653/4885ALDH1A1 1605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.