Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.62 |
| ▸ | TPMT | P51580 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27893364 | 0.90 | KMO (0.70) | KMOPOLBMAPTPIK3CASMN1; SMN2 | |
| SCHEMBL27472161 | 0.85 | MAP2 (0.49) | KMOMAPTSMN1; SMN2AKR1C3PRKDC | |
| SCHEMBL2724092 | 0.82 | KMO (0.60) | KMOPOLBMAPTPIK3CASMN1; SMN2 | |
| SCHEMBL593762 | 0.82 | KMO (0.60) | KMOPOLBMAPTPIK3CASMN1; SMN2 | |
| SCHEMBL24236054 | 0.82 | PRKDC (0.54) | MAPTSMN1; SMN2AKR1C3PRKDCALDH1A1 | |
| SCHEMBL1252295 | 0.82 | CHRM2 (0.57) | MAPTSMN1; SMN2ACLYAKR1C3PRKDC | |
| SCHEMBL4758239 | 0.81 | MAPK14 (0.47) | KMOMAPTSMN1; SMN2AKR1C3ALDH1A1 | |
| SCHEMBL545939 | 0.80 | TPMT (0.52) | TPMTPOLBSMN1; SMN2HCAR1ALDH1A1 | |
| SCHEMBL21712061 | 0.80 | KMO (0.57) | KMOPOLBMAPTPIK3CASMN1; SMN2 | |
| SCHEMBL15122791 | 0.78 | KMO (0.56) | KMOPOLBMAPTPIK3CASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |