Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27472161 | 0.83 | MAP2 (0.49) | MAPTSMN1; SMN2ALDH1A1TDP1KMO | |
| SCHEMBL4755079 | 0.82 | DDR1 (0.47) | MAPTALDH1A1LMNAKMT2APLOD2 | |
| SCHEMBL4757032 | 0.81 | KMO (0.62) | MAPTSMN1; SMN2ALDH1A1TDP1KMO | |
| SCHEMBL12524169 | 0.80 | HDAC6 (0.61) | MAPTSMN1; SMN2ALDH1A1TDP1HPGD | |
| SCHEMBL14697008 | 0.79 | KMO (0.68) | MAPK14MAPTSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL24236054 | 0.77 | PRKDC (0.54) | MAPTSMN1; SMN2ALDH1A1TDP1LMNA | |
| SCHEMBL1252295 | 0.77 | CHRM2 (0.57) | MAPTSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL4755128 | 0.77 | MAPK14 (0.44) | MAPK14MAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4755106 | 0.76 | PIK3CA (0.55) | MAPTSMN1; SMN2ALDH1A1TDP1HPGD | |
| SCHEMBL21638091 | 0.75 | KDM4E (0.61) | MAPTALDH1A1TDP1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |