Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.62 |
| ▸ | PDE1A | P54750 | 2/20 | 0.62 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.62 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757043 | 0.88 | NPC1 (0.70) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4756360 | 0.87 | NPC1 (0.55) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4757082 | 0.86 | NPC1 (0.54) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4756366 | 0.85 | NPC1 (0.53) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4757093 | 0.83 | SORT1 (0.47) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4756729 | 0.83 | SLC2A1 (0.46) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL10114456 | 0.83 | PDE5A (0.44) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4757020 | 0.82 | NPC1 (0.56) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4756354 | 0.82 | RAB9A (0.50) | PDE5APDE1APDE1BPDE1CNPC1 | |
| SCHEMBL4756956 | 0.81 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895752-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES L.C. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES, L.C. | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | PDE5A 4694/4885PDE1A 4846/4885PDE1B 4830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.