SCHEMBL4757074

SCHEMBL4757074

CC(=O)Oc1ccc(-c2nc(C(=O)NCC(=O)O)cc3ccccc23)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.55
HDAC3 O15379 2/20 0.46
HDAC4 P56524 2/20 0.46
HDAC1 Q13547 2/20 0.46
HDAC7 Q8WUI4 2/20 0.46
HDAC2 Q92769 2/20 0.46
HDAC10 Q969S8 2/20 0.46
HDAC11 Q96DB2 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
HDAC6 Q9UBN7 2/20 0.46
HDAC9 Q9UKV0 2/20 0.46
HDAC5 Q9UQL6 2/20 0.46
EGLN1 Q9GZT9 7/20 0.43
KDM4C Q9H3R0 1/20 0.43
THRA P10827 5/20 0.42
THRB P10828 5/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PDE5A O76074 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5034433 0.84 KDM4C (0.48) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL522077 0.73 EGLN1 (0.46) HPGDEGLN1KDM4CTHRATHRB
SCHEMBL4758413 0.72 EGLN1 (0.48) EGLN1KDM4CTHRATHRBFTO
SCHEMBL20477190 0.70 HPGD (0.68) HPGDKDM4EALDH1A1SMN1; SMN2
SCHEMBL28815511 0.69 ALDH1A1 (0.50) HPGDKDM4EALDH1A1SMN1; SMN2
SCHEMBL28230021 0.69 HPGD (0.67) HPGDKDM4EALDH1A1SMN1; SMN2
SCHEMBL8470610 0.68 CNR1 (0.44) HPGDKDM4EALDH1A1
SCHEMBL1208104 0.68 EGLN1 (0.62) HDAC3HDAC1HDAC2EGLN1KDM4C
SCHEMBL10985666 0.68 MEN1 (0.49) HPGDALDH1A1SMN1; SMN2
SCHEMBL7030966 0.67 P2RY12 (0.66) KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893186-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2008-03-05 EP claimed
WO-2006133391-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2006-12-14 WO claimed
WO-2009002533-A1 INFLAMMATORY BOWEL DISEASE THERAPIES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2008-12-31 WO disclosed
EP-1893186-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2008-03-05 EP disclosed
WO-2006133391-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2006-12-14 WO disclosed
EP-1644336-A1 NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN FIBROGEN, INC. (US) 2006-04-12 EP disclosed
WO-2004108681-A1 NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN FIBROGEN, INC. (US) 2004-12-16 WO disclosed