Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 5/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PEPD | P12955 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522330 | 0.81 | NPSR1 (0.44) | NPSR1ALDH1A1L3MBTL1ACE | |
| SCHEMBL522331 | 0.81 | NPSR1 (0.44) | NPSR1ALDH1A1L3MBTL1ACE | |
| SCHEMBL523208 | 0.81 | NPSR1 (0.44) | NPSR1ALDH1A1L3MBTL1ACE | |
| SCHEMBL523723 | 0.74 | EGLN1 (0.46) | ALDH1A1ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL523649 | 0.74 | EGLN1 (0.46) | ALDH1A1ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL523650 | 0.74 | EGLN1 (0.46) | ALDH1A1ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL1030669 | 0.69 | EGLN1 (0.36) | KDM4ELMNA | |
| SCHEMBL1028657 | 0.69 | EGLN1 (0.36) | KDM4ELMNA | |
| SCHEMBL2040068 | 0.66 | TSHR (0.47) | NPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL24728099 | 0.65 | ALDH1A1 (0.69) | NPSR1ALDH1A1L3MBTL1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009002533-A1 | INFLAMMATORY BOWEL DISEASE THERAPIES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2008-12-31 | — | — | WO | disclosed |