Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757090 | 1.00 | HTT (0.34) | HTTNPC1NEK2ATRRPS6KB1 | |
| SCHEMBL13985469 | 0.84 | MAPT (0.47) | MAPT | |
| SCHEMBL4754675 | 0.82 | MAPT (0.40) | HTTNPC1RPS6KB1KMT2ACYP3A4 | |
| SCHEMBL209374 | 0.82 | ABL1 (0.39) | HTTNPC1RPS6KB1GRM5MEN1 | |
| SCHEMBL209373 | 0.82 | ABL1 (0.39) | HTTNPC1RPS6KB1GRM5MEN1 | |
| SCHEMBL4755250 | 0.79 | LMNA (0.39) | HTTATRRPS6KB1GRM5MEN1 | |
| SCHEMBL4755253 | 0.79 | LMNA (0.39) | HTTATRRPS6KB1GRM5MEN1 | |
| SCHEMBL13985740 | 0.74 | LMNA (0.57) | KMT2ASMN1; SMN2 | |
| SCHEMBL15972434 | 0.69 | SMN1; SMN2 (0.41) | HTTNPC1MEN1KMT2AL3MBTL1 | |
| SCHEMBL15972432 | 0.69 | SMN1; SMN2 (0.41) | HTTNPC1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |