Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755253 | 1.00 | LMNA (0.39) | LMNAENPP1GRM5RPS6KB1ATR | |
| SCHEMBL13985648 | 0.84 | LMNA (0.47) | LMNAALDH1A1MAPT | |
| SCHEMBL209373 | 0.82 | ABL1 (0.39) | LMNAGRM5RPS6KB1ALDH1A1MAPT | |
| SCHEMBL209374 | 0.82 | ABL1 (0.39) | LMNAGRM5RPS6KB1ALDH1A1MAPT | |
| SCHEMBL4757090 | 0.79 | HTT (0.34) | GRM5RPS6KB1ATRMAPTMEN1 | |
| SCHEMBL4757089 | 0.79 | HTT (0.34) | GRM5RPS6KB1ATRMAPTMEN1 | |
| SCHEMBL15972434 | 0.69 | SMN1; SMN2 (0.41) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL15972432 | 0.69 | SMN1; SMN2 (0.41) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16318378 | 0.68 | VCAM1 (0.50) | LMNAALDH1A1MAPTMEN1GAA | |
| SCHEMBL16318379 | 0.68 | VCAM1 (0.50) | LMNAALDH1A1MAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |