SCHEMBL4757273

SCHEMBL4757273

Cc1[c]sc(-c2cccc(C)c2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.41
ALDH1A1 P00352 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
RAB9A P51151 2/20 0.38
HSD17B1 P14061 4/20 0.37
HSD17B2 P37059 4/20 0.37
NPC1 O15118 1/20 0.37
HPGD P15428 1/20 0.37
TSHR P16473 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
IDO1 P14902 1/20 0.36
METAP2 P50579 1/20 0.36
PTPN5 P54829 1/20 0.36
NISCH Q9Y2I1 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
AR P10275 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL694645 0.86 HSD17B1 (0.35) ALDH1A1MEN1KMT2ARAB9AHSD17B1
SCHEMBL694864 0.82 ESR1 (0.37) ACHEALDH1A1MEN1KMT2ARAB9A
SCHEMBL4757901 0.81 ESR2 (0.42) ALDH1A1KMT2AHSD17B1HSD17B2IDO1
SCHEMBL4756537 0.81 HSD17B1 (0.45) ACHEMEN1KMT2AHSD17B1HSD17B2
SCHEMBL28164657 0.79 HSD17B1 (0.32) ALDH1A1HSD17B1HSD17B2TSHR
SCHEMBL4754741 0.79 CYP1A1 (0.47) ACHERAB9AHSD17B1HSD17B2SMN1; SMN2
SCHEMBL4757541 0.74 MAPT (0.37) ALDH1A1MEN1KMT2ARAB9ANPC1
SCHEMBL2897272 0.74 IDO1 (0.41) ACHEALDH1A1MEN1KMT2ARAB9A
SCHEMBL1416534 0.73 ACHE (0.41) ACHEALDH1A1MEN1KMT2ARAB9A
SCHEMBL19741486 0.73 HSD17B1 (0.56) ACHEALDH1A1MEN1KMT2AHSD17B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008126684-A2 AGRICULTURAL COMPOSITION FOR CONTROLLING OR PREVENTING PLANT DISEASES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-23 WO disclosed