Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD4 | P21917 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985464 | 0.90 | AURKA (0.50) | AURKADRD2DRD4DRD3GNRHR | |
| SCHEMBL13985474 | 0.86 | AURKA (0.52) | AURKADRD2DRD4DRD3GNRHR | |
| SCHEMBL13985732 | 0.83 | AURKA (0.48) | AURKAGNRHRPARP1KCNH2 | |
| SCHEMBL4754714 | 0.82 | AURKA (0.52) | AURKADRD2DRD4DRD3KCNH2 | |
| SCHEMBL13985467 | 0.82 | AURKA (0.34) | AURKADRD2DRD4DRD3GNRHR | |
| SCHEMBL4756403 | 0.80 | AURKA (0.76) | AURKAKCNH2 | |
| SCHEMBL210868 | 0.79 | AURKA (0.50) | AURKAKCNH2 | |
| SCHEMBL4757483 | 0.78 | AURKA (0.59) | AURKAKCNH2 | |
| SCHEMBL13985465 | 0.77 | AURKA (0.51) | AURKADRD2DRD4DRD3KCNH2 | |
| SCHEMBL14495854 | 0.77 | AURKA (0.50) | AURKADRD2DRD4DRD3GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | claimed |
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |