Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16875754 | 0.79 | SMN1; SMN2 (0.32) | CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL27793166 | 0.78 | CYP2D6 (0.36) | CYP2D6CYP2C19PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL4574475 | 0.74 | HRH3 (0.43) | CYP2D6SMN1; SMN2F2ST14SLC18A3 | |
| SCHEMBL28781926 | 0.73 | BCHE (0.49) | — | |
| SCHEMBL29042805 | 0.72 | CHRNB2 (0.41) | CYP2D6SMN1; SMN2 | |
| SCHEMBL28972346 | 0.71 | ATM (0.30) | — | |
| SCHEMBL29094108 | 0.70 | TP53 (0.41) | CYP2D6SMN1; SMN2 | |
| SCHEMBL13655082 | 0.68 | — | — | |
| SCHEMBL15657167 | 0.68 | — | — | |
| SCHEMBL16621306 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001126-A1 | SUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS ANTIBATERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |