Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28675404 | 0.86 | PDK4 (0.55) | PDK4NAMPTCNR1JAK1GRM1 | |
| SCHEMBL8054238 | 0.85 | NAMPT (0.54) | PDK4NAMPTADORA1ELANEGRM1 | |
| SCHEMBL1274660 | 0.84 | PDK4 (0.51) | PDK4NAMPTELANEJAK1GRM1 | |
| SCHEMBL17535628 | 0.82 | PDK4 (0.46) | PDK4NAMPTADORA1ELANEJAK1 | |
| SCHEMBL16597542 | 0.81 | NAMPT (0.48) | PDK4NAMPTCNR1ADORA1JAK1 | |
| SCHEMBL31386526 | 0.81 | NAMPT (0.48) | PDK4NAMPTCNR1ADORA1JAK1 | |
| SCHEMBL28671220 | 0.81 | GRM1 (0.51) | PDK4NAMPTCNR1GRM1GRM5 | |
| SCHEMBL31053182 | 0.81 | GRM1 (0.51) | PDK4NAMPTCNR1GRM1GRM5 | |
| SCHEMBL4756934 | 0.80 | PPARG (0.44) | TRPV1 | |
| SCHEMBL19703166 | 0.80 | PDK4 (0.49) | PDK4NAMPTCNR1JAK1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |