Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.45 |
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698104 | 0.90 | HTR6 (0.45) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4702041 | 0.88 | HTR2C (0.50) | HTR6HTR2CSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4702065 | 0.88 | HTR6 (0.43) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4700190 | 0.85 | HTR6 (0.46) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4699429 | 0.85 | HTR6 (0.44) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4702831 | 0.83 | HTR1A (0.49) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4698811 | 0.82 | HTR2C (0.47) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4700935 | 0.82 | HTR2C (0.48) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4698501 | 0.82 | HTR2C (0.44) | HTR6HTR2CSIGMAR1HTR2AHTR7 | |
| SCHEMBL4698458 | 0.82 | HTR2C (0.46) | HTR6HTR2CSIGMAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613594-B1 | 4-(2-PHENYLSULFANYL-PHENYL)-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | LUNDBECK & CO AS H (DK) | 2008-03-26 | — | — | EP | claimed |