Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275696 | 0.73 | MAPKAPK2 (0.37) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL4760750 | 0.66 | NAAA (0.44) | ALDH1A1TSHR | |
| SCHEMBL27780541 | 0.66 | CHRM3 (0.54) | LMNASMN1; SMN2CHRM4CHRM3MEN1 | |
| SCHEMBL27659177 | 0.64 | CHRM3 (0.45) | SMN1; SMN2CHRM4CHRM3MEN1KMT2A | |
| SCHEMBL274363 | 0.64 | NR1H4 (0.59) | LMNAKDM4ESMN1; SMN2MEN1MAPT | |
| Hydrochloric Acid SCHEMBL28120286 | 0.63 | PKM (0.56) | LMNASMN1; SMN2CHRM4CHRM3MEN1 | |
| SCHEMBL274617 | 0.63 | NR1H4 (0.51) | LMNAKDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL274274 | 0.62 | NR1H4 (0.48) | LMNAKDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL28038407 | 0.62 | CHRM3 (0.50) | LMNASMN1; SMN2CHRM4CHRM3MEN1 | |
| SCHEMBL273348 | 0.62 | KDM4E (0.51) | LMNAKDM4ESMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963331-A1 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007070796-A1 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |