Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 7/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758995 | 0.85 | AVPR1A (0.49) | AVPR1AMGAMGAASIMGAM2 | |
| SCHEMBL4359077 | 0.79 | MGAM (0.53) | AVPR1AMGAMGAASIMGAM2 | |
| SCHEMBL4359923 | 0.68 | AVPR1A (0.58) | AVPR1AHDAC1HDAC6OXTR | |
| SCHEMBL5137269 | 0.66 | HTR3E (0.42) | AVPR1AMGAMGAASIMGAM2 | |
| SCHEMBL7276324 | 0.64 | GFER (0.62) | AVPR1AGAAHTTMAPK14GFER | |
| SCHEMBL8707863 | 0.64 | GFER (0.67) | AVPR1AHTTMAPK14GFERCCR5 | |
| SCHEMBL8708574 | 0.64 | GFER (0.59) | AVPR1AHTTMAPK14GFERCCR5 | |
| SCHEMBL289605 | 0.64 | POLB (0.74) | AVPR1AGAAHTTMAPK14GFER | |
| SCHEMBL13602796 | 0.64 | AVPR1A (0.78) | AVPR1AHTTMAPK14GFERCCR5 | |
| SCHEMBL4356598 | 0.64 | AVPR1A (0.78) | AVPR1AHTTMAPK14GFERCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973913-A1 | INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007077122-A1 | INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-12 | — | — | WO | disclosed |