SCHEMBL4759243

SCHEMBL4759243

Cc1nc2ccccc2cc1-n1ccnn1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
HPGD P15428 2/20 0.45
STAT3 P40763 2/20 0.45
KDM4E B2RXH2 1/20 0.45
GAA P10253 1/20 0.45
GLA P06280 1/20 0.42
MAPT P10636 1/20 0.42
ACHE P22303 1/20 0.42
NOTUM Q6P988 6/20 0.41
MBNL1 Q9NR56 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
HCRTR1 O43613 1/20 0.37
HCRTR2 O43614 1/20 0.37
KEAP1 Q14145 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CYP1A2 P05177 2/20 0.37
EGLN2 Q96KS0 1/20 0.36
PDE10A Q9Y233 1/20 0.36
PTPN2 P17706 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4758635 0.78 PLK1 (0.39) ALDH1A1KDM4EMAPTHCRTR1HCRTR2
SCHEMBL7831979 0.76 CYP1A2 (0.49) ALDH1A1KDM4EMAPTNOTUMHCRTR1
SCHEMBL15984728 0.71 NOTUM (0.47) NOTUMHCRTR1HCRTR2KEAP1CYP1A2
SCHEMBL20605667 0.71 NOTUM (0.50) NOTUMKEAP1CYP1A2
SCHEMBL29793813 0.71 NOTUM (0.50) NOTUMKEAP1CYP1A2
SCHEMBL241942 0.71 NOTUM (0.50) ALDH1A1HPGDNOTUMHCRTR1HCRTR2
SCHEMBL26078893 0.71 KDM4E (0.37) ALDH1A1HPGDKDM4EGAAGLA
SCHEMBL4760703 0.70 NPC1 (0.45) ALDH1A1HPGDKDM4EGLAMAPT
Hydrochloric Acid SCHEMBL5279937 0.69 NPC1 (0.44) ALDH1A1HPGDKDM4EGLAMAPT
SCHEMBL14842192 0.69 NOTUM (0.45) NOTUMHCRTR1HCRTR2KEAP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1745040-A1 AZABICYCLO(3.1.0) HEXANE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS GLAXO GROUP LIMITED (GB) 2007-01-24 EP claimed
WO-2005080382-A1 AZABICYCLO (3.1.0) HEXANE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS GLAXO GROUP LIMITED (GB) 2005-09-01 WO claimed
CN-101657443-A [1,2,3] triazole-substituted quinolines and coumarins as leukotriene biosynthesis inhibitors MERCK FROSST CANADA LTD CA 2010-02-24 CN disclosed
EP-1917013-A1 USE OF AZABICYCLO HEXANE DERIVATIVES GLAXO GROUP LIMITED (GB) 2008-05-07 EP disclosed
WO-2007022980-A1 USE OF AZABICYCLO HEXANE DERIVATIVES GLAXO GROUP LIMITED (GB) 2007-03-01 WO disclosed
EP-1745040-A1 AZABICYCLO(3.1.0) HEXANE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS GLAXO GROUP LIMITED (GB) 2007-01-24 EP disclosed
WO-2005080382-A1 AZABICYCLO (3.1.0) HEXANE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS GLAXO GROUP LIMITED (GB) 2005-09-01 WO disclosed