Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929041 | 0.87 | SMN1; SMN2 (0.47) | ACLYKMT2AMEN1GAAPTGDR2 | |
| SCHEMBL2930565 | 0.83 | ACLY (0.51) | ACLYPTGDR2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2930564 | 0.83 | ACLY (0.51) | ACLYPTGDR2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4757644 | 0.83 | ACLY (0.51) | ACLYPTGDR2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5823347 | 0.82 | ACLY (0.62) | ACLYKMT2AMEN1PTGDR2LMNA | |
| SCHEMBL2930161 | 0.81 | ACLY (0.55) | ACLYPTGDR2 | |
| SCHEMBL2928718 | 0.81 | ACLY (0.55) | ACLYPTGDR2 | |
| SCHEMBL15287559 | 0.77 | ACLY (0.49) | ACLYPTGDR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL15287543 | 0.77 | ACLY (0.49) | ACLYKMT2AHTR6 | |
| SCHEMBL2928016 | 0.75 | KMT2A (0.47) | KMT2AMEN1GAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534695-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2008-06-11 | — | — | EP | disclosed |
| EP-1534695-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004014851-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-02-19 | — | — | WO | disclosed |