Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 10/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.34 |
| ▸ | PARP1 | P09874 | 4/20 | 0.34 |
| ▸ | ACACA | Q13085 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.31 |
| ▸ | JUND | P17535 | 1/20 | 0.31 |
| ▸ | FOSB | P53539 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759730 | 0.89 | TNKS (0.34) | TNKSTNKS2PARP1ACACAACACB | |
| SCHEMBL2362040 | 0.89 | ACACB (0.35) | TNKSTNKS2PARP1ACACAACACB | |
| SCHEMBL4412678 | 0.89 | ACACB (0.35) | TNKSTNKS2PARP1ACACAACACB | |
| SCHEMBL4760383 | 0.88 | ACACB (0.34) | TNKSTNKS2PARP1ACACAACACB | |
| SCHEMBL4760480 | 0.88 | NOTUM (0.36) | ACACAACACB | |
| SCHEMBL4708996 | 0.87 | ACACA (0.35) | TNKSTNKS2PARP1ACACAACACB | |
| SCHEMBL4760214 | 0.87 | ACACA (0.34) | TNKSTNKS2PARP1ACACAACACB | |
| SCHEMBL4760019 | 0.86 | ACACA (0.32) | ACACAACACB | |
| SCHEMBL4708583 | 0.85 | XIAP (0.39) | TNKSTNKS2ACACAACACBPARP2 | |
| SCHEMBL4707267 | 0.85 | ACACA (0.38) | TNKSTNKS2ACACAACACBPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910375-A1 | SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | claimed |
| WO-2007011809-A1 | SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | claimed |
| EP-1910375-A1 | SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007011809-A1 | SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | disclosed |