Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21575588 | 0.88 | LMNA (0.50) | LMNACYP3A4MAOAMAOBALDH1A1 | |
| SCHEMBL4761158 | 0.83 | ALDH1A1 (0.48) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7536881 | 0.81 | GRM2 (0.42) | LMNAGRM2MAOAMAOBALDH1A1 | |
| SCHEMBL21575601 | 0.81 | LMNA (0.43) | LMNAMAOAMAOBALDH1A1BLM | |
| SCHEMBL26085728 | 0.76 | BLM (0.41) | LMNAMAOAMAOBBLMAR | |
| SCHEMBL7536901 | 0.75 | LMNA (0.45) | LMNAGRM2CYP3A4MAOAMAOB | |
| SCHEMBL7537633 | 0.73 | ALDH1A1 (0.45) | LMNAGRM2ALDH1A1KDM4EMEN1 | |
| SCHEMBL18655795 | 0.71 | CYP1A2 (0.52) | LMNAGRM2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14273828 | 0.71 | LMNA (0.39) | LMNAALDH1A1MEN1KMT2ABLM | |
| SCHEMBL14093836 | 0.71 | CYP1A2 (0.56) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101404985-A | Autoimmune conditions and NADPH oxidase defects | BIOVITRUM AB PUBL (SE) | 2009-04-08 | — | — | CN | disclosed |
| EP-2004159-A1 | AUTOIMMUNE CONDITIONS AND NADPH OXIDASE DEFECTS | Biovitrum AB (publ) (SE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007104790-A1 | AUTOIMMUNE CONDITIONS AND NADPH OXIDASE DEFECTS | BIOVITRUM AB (PUBL) (SE) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007104790-A1 | AUTOIMMUNE CONDITIONS AND NADPH OXIDASE DEFECTS | BIOVITRUM AB (PUBL) (SE) | 2007-09-20 | — | — | WO | disclosed |