Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | KAT7 | O95251 | 1/20 | 0.32 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709673 | 0.82 | MEN1 (0.39) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL4760926 | 0.71 | KMT2A (0.40) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL28344917 | 0.71 | HTT (0.50) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL4709265 | 0.69 | BRD4 (0.37) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL22163720 | 0.66 | RXRA (0.50) | HTTHDAC1HDAC6RARARARB | |
| SCHEMBL4711568 | 0.66 | MEN1 (0.35) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL4709702 | 0.66 | HTT (0.36) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL14256403 | 0.65 | HTT (0.68) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL14987117 | 0.65 | HTT (0.63) | HTTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL10244204 | 0.64 | HTT (0.57) | HTTKMT2AMEN1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| US-6777418-B2 | FOR TREATING OR PREVENTING EMPHYSEMA, CANCER AND DERMATOLOGICAL DISORDERS | SYNTEX (U.S.A.) LLC | 2004-08-17 | — | — | US | disclosed |