Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153812 | 1.00 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL19527776 | 0.83 | DHFR (0.46) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL3154239 | 0.82 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL3149891 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MAPK1HPGDNPC1RAB9A | |
| SCHEMBL3149885 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MAPK1HPGDNPC1RAB9A | |
| SCHEMBL30079702 | 0.77 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL4451541 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL10887533 | 0.76 | POLB (0.44) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL19612210 | 0.75 | IDO1 (0.36) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR | |
| SCHEMBL19527479 | 0.75 | TP53 (0.41) | ALDH1A1SMN1; SMN2MAPK1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |