⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22558219 | 0.82 | ALDH1A1 (0.38) | — | |
| SCHEMBL704696 | 0.80 | ALDH1A1 (0.35) | — | |
| SCHEMBL704202 | 0.80 | ALDH1A1 (0.35) | — | |
| SCHEMBL435046 | 0.79 | ALDH1A1 (0.36) | — | |
| SCHEMBL949196 | 0.79 | — | — | |
| SCHEMBL1953218 | 0.78 | — | — | |
| SCHEMBL3791516 | 0.78 | ALDH1A1 (0.39) | — | |
| SCHEMBL5839559 | 0.77 | ALDH1A1 (0.44) | — | |
| SCHEMBL4636155 | 0.76 | — | — | |
| SCHEMBL705061 | 0.76 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3281941-B1 | PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID | ZENTIVA KS (CZ) | 2019-07-24 | — | — | EP | claimed |
| EP-3281941-A1 | PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID | Zentiva K.S. (CZ) | 2018-02-14 | — | — | EP | claimed |
| EP-3281941-B1 | PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID | ZENTIVA KS (CZ) | 2019-07-24 | — | — | EP | disclosed |
| EP-3281941-A1 | PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID | Zentiva K.S. (CZ) | 2018-02-14 | — | — | EP | disclosed |
| EP-2912120-B1 | ANTIFOULING COATING COMPOSITION | JOTUN AS (NO) | 2017-12-20 | — | — | EP | disclosed |
| EP-2725073-B1 | Antifouling coating composition | JOTUN AS (NO) | 2016-08-03 | — | — | EP | disclosed |
| EP-2912120-A1 | ANTIFOULING COATING COMPOSITION | Jotun A/S (NO) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014064049-A1 | ANTIFOULING COATING COMPOSITION | JOTUN A/S (NO) | 2014-05-01 | — | — | WO | disclosed |
| WO-2014064048-A1 | ANTIFOULING COATING COMPOSITION | JOTUN A/S (NO) | 2014-05-01 | — | — | WO | disclosed |
| EP-2725073-A1 | Antifouling coating composition | Jotun A/S (NO) | 2014-04-30 | — | — | EP | disclosed |
| EP-2708594-A1 | Cleaning process | Jotun A/S (NO) | 2014-03-19 | — | — | EP | disclosed |
| EP-2173780-A1 | BRANCHED POLYMER AND ANTIFOULING COATING COMPOSITION COMPRISING THE POLYMER | Jotun A/S (NO) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009149919-A1 | BINDER FOR ANTIFOULING COATING COMPOSITION AND ANTIFOULING COATING COMPOSITION COMPRISING BINDER | JOTUN A/S (NO) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009007276-A1 | BRANCHED POLYMER AND ANTIFOULING COATING COMPOSITION COMPRISING THE POLYMER | JOTUN A/S (NO) | 2009-01-15 | — | — | WO | disclosed |
| EP-1487928-B1 | FILM-FORMING POLYMER AND ANTIFOULING PAINT | JOTUN AS (NO) | 2008-08-13 | — | — | EP | disclosed |
| EP-1487928-A1 | FILM-FORMING POLYMER AND ANTIFOULING PAINT | Jotun AS (NO) | 2004-12-22 | — | — | EP | disclosed |
| WO-2004005302-A1 | PROCESS FOR THE PREPARATION OF ACYLOXYSILANES | SIGMA COATINGS B.V. (NL) | 2004-01-15 | — | — | WO | disclosed |
| EP-1378514-A1 | Process for the preparation of acyloxysilanes | SigmaKalon Group B.V. (NL) | 2004-01-07 | — | — | EP | disclosed |
| WO-2003080747-A1 | FILM-FORMING POLYMER AND ANTIFOULING PAINT | JOTUN AS (NO) | 2003-10-02 | — | — | WO | disclosed |
| US-4479966-A | 6,9-Methano-PGI2 analogues | ONO PHARMACEUTICAL COMPANY, LTD. (JP) | 1984-10-30 | — | — | US | disclosed |