Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.44 |
| ▸ | MARS1 | P56192 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2696570 | 0.89 | ALPL (0.46) | PTPN1ALDH1A1HPGDMRGPRX4KDM4E | |
| SCHEMBL476338 | 0.84 | PTPN1 (0.47) | PTPN1PTPRCPTPN2ALDH1A1HPGD | |
| SCHEMBL476369 | 0.82 | SRD5A2 (0.45) | PTPN1MARS1SRD5A2ALDH1A1HPGD | |
| SCHEMBL12483906 | 0.74 | ALPL (0.44) | HPGDMRGPRX4KDM4EMAPT | |
| SCHEMBL2698949 | 0.73 | GRM6 (0.43) | PTPN1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL1851230 | 0.72 | OPRD1 (0.57) | PTPN1MARS1SRD5A2ALDH1A1HPGD | |
| SCHEMBL2682560 | 0.72 | TP53 (0.48) | MARS1ALDH1A1KDM4EMAPT | |
| SCHEMBL3559754 | 0.72 | SRD5A2 (0.41) | MARS1SRD5A2KDM4EMAPT | |
| SCHEMBL4066722 | 0.71 | PTPN1 (0.41) | PTPN1PTPRCPTPN2ALDH1A1HPGD | |
| SCHEMBL3549304 | 0.70 | SRD5A2 (0.45) | PTPN1MARS1SRD5A2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411383-B1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-22 | — | — | EP | disclosed |
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |