Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 15/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476257 | 0.85 | CNR1 (0.33) | CNR1CNR2TP53MDM2KMT2A | |
| SCHEMBL476187 | 0.81 | ROCK2 (0.37) | CNR1CNR2TP53MDM2 | |
| SCHEMBL476188 | 0.76 | CNR1 (0.38) | CNR1CNR2TP53MDM2NPC1 | |
| SCHEMBL476315 | 0.70 | ROCK2 (0.35) | CNR1CNR2 | |
| SCHEMBL476368 | 0.69 | PTGDR2 (0.35) | CNR1CNR2 | |
| SCHEMBL476391 | 0.68 | CNR1 (0.39) | CNR1TP53MDM2 | |
| SCHEMBL476255 | 0.68 | PTGDR2 (0.34) | CNR1CNR2 | |
| SCHEMBL476225 | 0.67 | CNR1 (0.38) | CNR1TP53MDM2 | |
| SCHEMBL476418 | 0.67 | CNR1 (0.32) | CNR1CNR2 | |
| SCHEMBL476352 | 0.66 | CNR1 (0.37) | CNR1CNR2TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |