SCHEMBL476315

SCHEMBL476315

COc1c(C(=O)NC(=O)C2(c3ccccc3)CCNCC2)sc(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.35
HDAC1 Q13547 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
ACLY P53396 1/20 0.34
ITGA4 P13612 2/20 0.34
ITGB7 P26010 2/20 0.34
OPRM1 P35372 1/20 0.34
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
EPHX2 P34913 1/20 0.33
CNR1 P21554 2/20 0.33
CNR2 P34972 2/20 0.33
TACR1 P25103 1/20 0.33
CCR8 P51685 2/20 0.32
KCNH2 Q12809 1/20 0.32
MARS1 P56192 1/20 0.32
ITGB1 P05556 1/20 0.32
KDM4E B2RXH2 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL476368 0.90 PTGDR2 (0.35) ROCK2HDAC1PTGDR2ITGA4ITGB7
SCHEMBL476255 0.88 PTGDR2 (0.34) ROCK2HDAC1PTGDR2OPRM1EPHX2
SCHEMBL476187 0.88 ROCK2 (0.37) ROCK2HDAC1PTGDR2OPRM1EPHX2
SCHEMBL476410 0.87 PRKAB2 (0.35) ROCK2HDAC1PTGDR2OPRM1EPHX2
SCHEMBL476251 0.87 PTGDR2 (0.32) ROCK2HDAC1PTGDR2OPRM1EPHX2
SCHEMBL476455 0.82 PTGDR2 (0.35) ROCK2HDAC1PTGDR2ITGA4ITGB7
SCHEMBL1848299 0.81 EP300 (0.47) ROCK2HDAC1ALDH1A1SMN1; SMN2CNR1
SCHEMBL476277 0.79 PTGDR2 (0.33) ROCK2HDAC1PTGDR2ITGA4ITGB7
SCHEMBL476391 0.76 CNR1 (0.39) CNR1
SCHEMBL476314 0.76 CNR1 (0.51) CNR1CNR2TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2411383-A1 DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-02-01 EP disclosed
WO-2010109150-A1 DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-09-30 WO disclosed