Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.35 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.31 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590598 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL1256533 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL3590602 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL882664 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL882674 | 0.75 | ALDH1A1 (0.45) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL2012751 | 0.75 | ALDH1A1 (0.45) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL14306871 | 0.75 | ALDH1A1 (0.45) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL12609250 | 0.73 | ALDH1A1 (0.44) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL21935430 | 0.72 | ALDH1A1 (0.42) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL2037923 | 0.72 | KDM4E (0.49) | ALDH1A1KDM4EKDM5AKDM3AJMJD1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963319-A1 | HETEROARYLPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007071621-A1 | HETEROARYLPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-28 | — | — | WO | disclosed |