Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 14/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718781 | 0.88 | RPS6KA5 (0.62) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| Hydrochloric Acid SCHEMBL4717613 | 0.87 | RPS6KA5 (0.61) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4762237 | 0.87 | RPS6KA5 (0.58) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL14252436 | 0.86 | RPS6KA5 (0.64) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL5468933 | 0.86 | RPS6KA5 (0.59) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4762033 | 0.85 | RPS6KA5 (0.61) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| Hydrochloric Acid SCHEMBL4715944 | 0.85 | RPS6KA5 (0.63) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL5467956 | 0.85 | RPS6KA5 (0.57) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL6648964 | 0.84 | RPS6KA5 (0.72) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4717439 | 0.84 | RPS6KA5 (0.64) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689393-A4 | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-12-17 | — | — | EP | claimed |
| JP-2007507547-A | — | — | 2007-03-29 | — | — | JP | claimed |
| EP-1689393-A2 | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-08-16 | — | — | EP | claimed |
| WO-2005037198-A2 | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-04-28 | — | — | WO | claimed |