Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.39 |
| ▸ | CBX7 | O95931 | 3/20 | 0.38 |
| ▸ | CDYL2 | Q8N8U2 | 3/20 | 0.38 |
| ▸ | CDYL | Q9Y232 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 2/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256058 | 0.83 | GPR119 (0.50) | KDM4E | |
| SCHEMBL16456347 | 0.79 | KDM4E (0.44) | TNKSKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16456021 | 0.79 | KDM4E (0.44) | TNKSKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4899696 | 0.79 | TP53 (0.45) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL15205382 | 0.77 | HTR3A (0.38) | KDM4EALDH1A1PDE4BPDE4D | |
| SCHEMBL15205381 | 0.77 | HTR3A (0.38) | KDM4EALDH1A1PDE4BPDE4D | |
| SCHEMBL23236023 | 0.76 | TNKS (0.58) | TNKSPARP1PARP2HSD11B1CALCRL | |
| SCHEMBL16455930 | 0.76 | KDM4E (0.41) | TNKSKDM4EALDH1A1 | |
| SCHEMBL15204431 | 0.75 | KDM4E (0.42) | TNKSHSD11B1KDM4EALDH1A1 | |
| SCHEMBL15204430 | 0.75 | KDM4E (0.42) | TNKSHSD11B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188478-A1 | Compounds Useful In Therapy | PFIZER INC. | 2008-08-07 | — | — | US | disclosed |
| EP-1877399-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | Pfizer Limited (GB) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114706-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | PFIZER LIMITED (GB) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188478-A1 | Compounds Useful In Therapy | AVPR1A, AVPR1B, AVPR2 | TNKS 4551/4885PARP1 3651/4885PARP2 3734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.