Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763412 | 0.81 | PLK1 (0.51) | — | |
| SCHEMBL15441142 | 0.80 | TRPV4 (0.82) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL15441180 | 0.77 | TRPV4 (1.00) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL15441278 | 0.77 | TRPV4 (0.87) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL1066093 | 0.77 | TRPV4 (0.77) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL4790332 | 0.77 | — | — | |
| SCHEMBL15442211 | 0.76 | TRPV4 (1.00) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL15441586 | 0.76 | TRPV4 (1.00) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL15441297 | 0.75 | MAPK1 (1.00) | TRPV4MAPK1TDP1ALDH1A1MAPT | |
| SCHEMBL15441639 | 0.75 | ALDH1A1 (1.00) | TRPV4MAPK1TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |