Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CCND2 | P30279 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527782 | 0.88 | CSF1R (0.57) | CSF1RCCNT1CDK9AURKACDK1 | |
| SCHEMBL4767401 | 0.84 | CSF1R (0.86) | CSF1RAURKACDK1CCNB1CDK4 | |
| SCHEMBL4884345 | 0.84 | CSF1R (0.81) | CSF1RAURKACDK1CDK4WEE1 | |
| SCHEMBL4889961 | 0.84 | CSF1R (0.60) | CSF1RCCNT1CDK9AURKACDK1 | |
| SCHEMBL4791572 | 0.83 | CSF1R (0.86) | CSF1RAURKACDK1CCNB1CDK4 | |
| SCHEMBL4891427 | 0.83 | CSF1R (0.60) | CSF1RAURKACDK1SYKCDK4 | |
| SCHEMBL4891439 | 0.83 | CSF1R (0.69) | CSF1RSYKCDK4CCND1CCND2 | |
| SCHEMBL4890824 | 0.83 | CSF1R (0.66) | CSF1RCCNT1CDK9CDK4CCND1 | |
| SCHEMBL4882532 | 0.82 | CSF1R (0.80) | CSF1R | |
| SCHEMBL4885531 | 0.82 | CSF1R (0.68) | CSF1RSYKCDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |