Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.61 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760858 | 0.82 | GPR35 (0.49) | PTPN1GPR35HSD17B10TPMTPTPRC | |
| SCHEMBL2682770 | 0.82 | MAPT (0.48) | PTPN1GPR35HSD17B10ALDH1A1HPGD | |
| SCHEMBL4066722 | 0.81 | PTPN1 (0.41) | PTPN1GPR35HSD17B10TPMTPTPRC | |
| SCHEMBL2761037 | 0.78 | CA1 (0.39) | PTPN1HSD17B10TPMTALDH1A1HPGD | |
| SCHEMBL3908645 | 0.78 | PTPN1 (0.71) | PTPN1PTPRCPTPN2 | |
| SCHEMBL3908732 | 0.77 | PTPN1 (0.53) | PTPN1GPR35PTPRCPTPN2 | |
| Hydrochloric Acid SCHEMBL11597062 | 0.76 | CA1 (0.38) | PTPN1HSD17B10TPMTALDH1A1HPGD | |
| SCHEMBL3913634 | 0.76 | PTPN1 (0.56) | PTPN1GPR35PTPRCPTPN2 | |
| SCHEMBL4582179 | 0.73 | GPR35 (0.54) | PTPN1GPR35PTPRCPTPN2ALDH1A1 | |
| SCHEMBL6262160 | 0.73 | PTPN1 (0.71) | PTPN1GPR35PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117616011-A | Inhibitors of transglutaminase | 策迪拉有限公司 | 2024-02-27 | — | — | CN | disclosed |
| WO-2023110138-A1 | INHIBITORS OF TRANSGLUTAMINASES | ZEDIRA GMBH (DE) | 2023-06-22 | — | — | WO | disclosed |
| EP-2411383-B1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-22 | — | — | EP | disclosed |
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |