Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763276 | 1.00 | HTR1A (0.44) | HTR1ADRD2HTR2AHTR1DTDP1 | |
| SCHEMBL3960016 | 0.92 | HTR1D (0.40) | HTR1ADRD2HTR2AHTR1DTDP1 | |
| SCHEMBL3960010 | 0.92 | HTR1D (0.40) | HTR1ADRD2HTR2AHTR1DTDP1 | |
| Hydrochloric Acid SCHEMBL27740058 | 0.91 | HTR1D (0.39) | HTR1ADRD2HTR2AHTR1DTDP1 | |
| Hydrochloric Acid SCHEMBL27740057 | 0.91 | HTR1D (0.39) | HTR1ADRD2HTR2AHTR1DTDP1 | |
| SCHEMBL28775840 | 0.86 | HTR1A (0.35) | HTR1ADRD2HTR1DTDP1KDM4E | |
| SCHEMBL5423282 | 0.85 | HTR1D (0.39) | HTR1ADRD2HTR1DTDP1KDM4E | |
| SCHEMBL4763248 | 0.85 | HTR1D (0.39) | HTR1ADRD2HTR1DTDP1KDM4E | |
| SCHEMBL11839372 | 0.85 | HTR1A (0.52) | HTR1ADRD2HTR2AKDM4ESIGMAR1 | |
| SCHEMBL6789252 | 0.84 | HTR1A (0.47) | HTR1ADRD2HTR2AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928860-A1 | NOVEL 2,3-DIHYDROINDOLE COMPOUNDS | H.Lundbeck A/S (DK) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007019867-A1 | NOVEL 2,3-DIHYDROINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 2007-02-22 | — | — | WO | disclosed |