Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763446 | 1.00 | MAPT (0.52) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4763895 | 0.93 | MAPT (0.45) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4763887 | 0.93 | MAPT (0.45) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4767904 | 0.91 | MAPT (0.44) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4763160 | 0.87 | PARG (0.42) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4763164 | 0.87 | PARG (0.42) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4767913 | 0.87 | MAPT (0.43) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4767908 | 0.87 | MAPT (0.43) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4763890 | 0.87 | MAPT (0.46) | MAPTALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL4763883 | 0.87 | MAPT (0.46) | MAPTALDH1A1MAPK1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |