Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PDE1A | P54750 | 3/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767913 | 1.00 | MAPT (0.43) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4767864 | 0.91 | MAPT (0.40) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4767868 | 0.91 | MAPT (0.40) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4762387 | 0.88 | ALDH1A1 (0.38) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4762384 | 0.88 | ALDH1A1 (0.38) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4763446 | 0.87 | MAPT (0.52) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4763451 | 0.87 | MAPT (0.52) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4769240 | 0.86 | NPBWR1 (0.40) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4769244 | 0.86 | NPBWR1 (0.40) | MAPTALDH1A1MAPK1PDE1APDE1B | |
| SCHEMBL4762428 | 0.85 | MAPT (0.39) | MAPTALDH1A1MAPK1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |