Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792234 | 0.88 | — | — | |
| SCHEMBL4763128 | 0.88 | P2RX3 (0.41) | SMN1; SMN2P2RX3MAPT | |
| SCHEMBL4763129 | 0.76 | — | — | |
| SCHEMBL4498797 | 0.74 | TSHR (0.46) | LMNASMN1; SMN2TSHRMAPK1POLB | |
| SCHEMBL4762442 | 0.74 | — | — | |
| SCHEMBL4761787 | 0.68 | — | — | |
| SCHEMBL4504404 | 0.67 | PPARG (0.40) | — | |
| SCHEMBL4504403 | 0.67 | PPARG (0.40) | — | |
| SCHEMBL4507919 | 0.63 | KMO (0.38) | LMNATSHRMAPK1POLBMAPT | |
| SCHEMBL4510686 | 0.62 | KMT2A (0.52) | LMNASMN1; SMN2TSHRMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |