Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.56 |
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596827 | 0.90 | AQP1 (0.53) | AQP1PARP1BRD4L3MBTL1HTR1A | |
| SCHEMBL4712234 | 0.88 | AQP1 (0.67) | AQP1PARP1BRD4HTR1ACREBBP | |
| SCHEMBL4764341 | 0.86 | AQP1 (0.55) | AQP1PARP1NOTUML3MBTL1MAPK14 | |
| SCHEMBL4713102 | 0.85 | AQP1 (0.54) | AQP1PARP1BRD4L3MBTL1HTR1A | |
| SCHEMBL14113467 | 0.84 | AQP1 (0.80) | AQP1PARP1NOTUML3MBTL1SLC6A4 | |
| SCHEMBL4229976 | 0.84 | AQP1 (0.62) | AQP1NOTUML3MBTL1 | |
| SCHEMBL5605280 | 0.84 | AQP1 (0.58) | AQP1NOTUML3MBTL1 | |
| SCHEMBL4226033 | 0.84 | AQP1 (0.80) | AQP1PARP1NOTUML3MBTL1SLC6A4 | |
| SCHEMBL4229969 | 0.84 | AQP1 (0.62) | AQP1NOTUML3MBTL1 | |
| SCHEMBL4762568 | 0.82 | PARP1 (0.48) | AQP1PARP1BRD4HTR1ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871356-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116170-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | claimed |