Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.50 |
| ▸ | SMO | Q99835 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285315 | 0.89 | NR3C1 (0.55) | NR3C1SMOCYP11B1CYP11B2 | |
| SCHEMBL4275048 | 0.86 | NR3C1 (0.61) | NR3C1SMO | |
| SCHEMBL4283064 | 0.79 | NR3C1 (0.63) | NR3C1SMOCYP11B1CYP11B2 | |
| SCHEMBL3014503 | 0.78 | NR3C1 (0.63) | NR3C1SMO | |
| SCHEMBL3014504 | 0.78 | NR3C1 (0.63) | NR3C1SMO | |
| SCHEMBL3003795 | 0.78 | NR3C1 (0.63) | NR3C1SMO | |
| SCHEMBL3003798 | 0.78 | NR3C1 (0.63) | NR3C1SMO | |
| SCHEMBL3003792 | 0.78 | NR3C1 (0.63) | NR3C1SMO | |
| SCHEMBL3020983 | 0.78 | NR3C1 (0.60) | NR3C1SMO | |
| SCHEMBL13611164 | 0.77 | NR3C1 (0.45) | NR3C1SMOCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893588-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135826-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | WO | claimed |