Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL61003 | 1.00 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL4920381 | 0.98 | TGFBR1 (0.42) | TGFBR1KDM4EALDH1A1 | |
| SCHEMBL33606 | 0.98 | TGFBR1 (0.44) | TGFBR1KDM4EALDH1A1 | |
| Iodide SCHEMBL28119502 | 0.96 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1 | |
| Water SCHEMBL9092030 | 0.96 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1 | |
| Bromide SCHEMBL1953376 | 0.96 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1 | |
| Fluoride Ion SCHEMBL17105875 | 0.96 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28144940 | 0.96 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL28716903 | 0.93 | TDP1 (0.40) | TGFBR1KDM4E | |
| Phosphonic Acid SCHEMBL28462095 | 0.93 | TGFBR1 (0.39) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776176-A4 | COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER | UNIV MCMASTER (CA) | 2008-12-24 | — | — | EP | claimed |
| EP-1776176-A1 | COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER | McMaster University (CA) | 2007-04-25 | — | — | EP | claimed |
| WO-2006015495-A1 | COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER | MCMASTER UNIVERSITY (CA) | 2006-02-16 | — | — | WO | claimed |