Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30438223 | 0.80 | L3MBTL1 (0.47) | LMNAL3MBTL1KMT2APOLBMAPT | |
| SCHEMBL4537895 | 0.79 | L3MBTL1 (0.46) | LMNAL3MBTL1KMT2AMAPTMAPK8 | |
| SCHEMBL1291161 | 0.77 | L3MBTL1 (0.43) | LMNAL3MBTL1KMT2AKDM4EMAPT | |
| SCHEMBL27581563 | 0.77 | L3MBTL1 (0.45) | LMNAL3MBTL1KMT2APOLBMAPK8 | |
| SCHEMBL27870422 | 0.77 | L3MBTL1 (0.48) | LMNAL3MBTL1KMT2AKDM4EPOLB | |
| SCHEMBL7603398 | 0.75 | KMT2A (0.45) | LMNAL3MBTL1KMT2AKDM4EMEN1 | |
| SCHEMBL4537897 | 0.75 | L3MBTL1 (0.43) | LMNAL3MBTL1KMT2AMAPTMAPK8 | |
| SCHEMBL27938524 | 0.74 | FAAH (0.59) | L3MBTL1KMT2AKDM4EMEN1POLB | |
| SCHEMBL15880497 | 0.74 | HTT (0.42) | LMNAL3MBTL1KMT2AMEN1MAPT | |
| SCHEMBL28522946 | 0.73 | KDM4E (0.46) | LMNAL3MBTL1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2410858-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | Merck Sharp & Dohme Corp. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111059-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME CORP. (US) | 2010-09-30 | — | — | WO | disclosed |