Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764562 | 0.95 | AGTR1 (0.45) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4774354 | 0.91 | EDNRA (0.44) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL5532211 | 0.90 | EDNRA (0.44) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL5789921 | 0.90 | EDNRA (0.44) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4766229 | 0.88 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL5528397 | 0.88 | AGTR1 (0.54) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL7849912 | 0.88 | AGTR1 (0.54) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4769995 | 0.87 | EDNRA (0.43) | EDNRAEDNRB | |
| SCHEMBL4769227 | 0.87 | AGTR1 (0.54) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4771679 | 0.86 | EDNRA (0.45) | EDNRAEDNRBAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | claimed |
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-07-01 | — | — | US | claimed |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-06-03 | — | — | US | claimed |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2002-10-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | EDNRA 3/4885EDNRB 1/4885AGTR1 4/4885 |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | EDNRA 3/4885EDNRB 1/4885AGTR1 4/4885 |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | EDNRA 3/4885EDNRB 1/4885AGTR1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.