Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585527 | 0.93 | KDM4E (0.41) | KDM4ETDP1MMP3ENPP2MAPT | |
| Bromide SCHEMBL4765026 | 0.89 | KDM4E (0.39) | KDM4ETDP1MMP3ENPP2MAPT | |
| SCHEMBL1050898 | 0.78 | ACHE (0.48) | KDM4ETDP1MMP3ENPP2ACHE | |
| SCHEMBL8658364 | 0.78 | KDM4E (0.48) | KDM4ETDP1MMP3ENPP2MAPT | |
| SCHEMBL502201 | 0.78 | KDM4E (0.48) | KDM4ETDP1MMP3ENPP2MAPT | |
| SCHEMBL4433177 | 0.73 | KDM4E (0.41) | KDM4ETDP1MMP3ENPP2MAPT | |
| SCHEMBL18860546 | 0.70 | HCAR1 (0.40) | MAPTHCAR1IDO1ACHEMEN1 | |
| SCHEMBL25170271 | 0.69 | CA12 (0.48) | KDM4ETDP1MMP3ENPP2HCAR1 | |
| SCHEMBL1072135 | 0.69 | KDM4E (0.41) | KDM4ETDP1ENPP2MAPTNPC1 | |
| SCHEMBL334575 | 0.69 | KDM4E (0.41) | KDM4ETDP1MMP3ENPP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |